Ambergris Ketone (Iso E Super Equivalent)
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Aroma Chemicals

Ambergris Ketone (Iso E Super Equivalent)

Unravel Perfumery ·Aroma Chemicals

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Scent FamilyWoodyAmberCedarVelvety
Restricted under the IFRA Standards (51st Amendment, in force). Maximum in fine fragrance (Category 4): 20%; other product types have different limits. EU: Added to the EU's expanded fragrance-allergen list (Regulation 2023/1545): declare on EU cosmetic labels above 0.001% (leave-on) or 0.01% (rinse-off).

CAS 54464-57-2 · Woody · Amber · IFRA restricted (fine fragrance max 20%)

Ambergris Ketone is OTNE, the smooth woody-amber molecule most perfumers know as Iso E Super. It is the soft, velvety cedar glow that sits under a huge number of modern fragrances. It is so subtle that some people can barely smell it, yet it makes everything around it feel bigger and smoother.

What it smells like

Dry, velvety cedarwood with a soft amber warmth and a faint vetiver-like edge. It is transparent rather than heavy and lasts for many hours.

How perfumers use it

Use it generously as a woody backbone: it blends into almost any accord and lifts florals, citruses and musks. Paired with Ambroxan and a musk it forms the classic woody-amber-musk skin scent. It is IFRA restricted, so check the limit for your product category, especially at the high levels this material invites.

Blends well with: Ambroxan, Hedione, Musk G / Galaxolide, Cedrol, Bergamot.

Equivalent to ISO E Super

Iso E Super is IFF's trade name for OTNE, and Ambergris Ketone is OTNE too, so they are the same molecule and you can swap them 1:1. Prefer the original brand? We also stock ISO E Super IFF.

IFRA & regulatory

Restricted under the IFRA Standards (51st Amendment, in force). Maximum in fine fragrance (Category 4): 20%; other product types have different limits. EU: Added to the EU's expanded fragrance-allergen list (Regulation 2023/1545): declare on EU cosmetic labels above 0.001% (leave-on) or 0.01% (rinse-off).

For use in perfumery, cosmetics and fragrance manufacturing only. Not for ingestion. Handle neat material with gloves and good ventilation. The certificate of analysis (COA) and safety data sheet (SDS) are available on request.

Frequently asked questions

Is Ambergris Ketone the same as Iso E Super?

Yes. Both are OTNE (CAS 54464-57-2); Iso E Super is IFF's brand name for it.

Why can't I smell Iso E Super / OTNE?

Some people have a partial anosmia to OTNE. It still changes how a blend smells, adding smoothness and radiance, even when it is hard to smell on its own.

Is OTNE restricted by IFRA?

Restricted under the IFRA Standards (51st Amendment, in force). Maximum in fine fragrance (Category 4): 20%; other product types have different limits. EU: Added to the EU's expanded fragrance-allergen list (Regulation 2023/1545): declare on EU cosmetic labels above 0.001% (leave-on) or 0.01% (rinse-off).

Browse more aroma chemicals for perfumery. Technical and regulatory data checked 21 September 2026 against the IFRA Standards (51st Amendment) and the 52nd Amendment consultation outcome.

Pair & layer

Works beautifully with

Starting points built from our own catalogue. Dosages are % of the finished oil or parts by weight; adjust by smell.

Accord

Clean woody-amber skin scent

The modern 'skin scent': transparent woods, soft musk and a mineral ambergris glow that lasts all day.

Use at 10–25% of your perfume concentrate, or wear as a minimalist scent on its own.

Accord

Dry cedar-amber

Dry, modern woody-amber with a plush musky warmth. (Amber Xtreme as a 10% dilution.)

Use at 10–25% of a woody or masculine formula.

Suggested levels are kept within IFRA fine-fragrance limits for the added material. Your oil already contains other materials, so check the finished blend against the IFRA Standards before selling.

Official documents and compliance certificates for this product. Always verify IFRA usage levels from the official compliance sheets before formulation.

IFRA Compliance SheetPDF
Safety Data Sheet (SDS)PDF

Documents will appear here once uploaded via the custom.certifications metafield.Request via WhatsApp →

Orders dispatched within 1–2 business days. Standard delivery 4–7 business days across India. Free shipping on orders above ₹999 across India.

Opened fragrance products cannot be returned. Damaged or incorrect items resolved within 48 hours of reporting with photo.

Technical profile

Ambergris Ketone (Iso E Super Equivalent), at a glance

Technical & regulatory data checked 21 Sep 2026

Molecule
C16H26O
Chemical name
OTNE (1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-tetramethyl-2-naphthyl)ethanone)
CAS number
54464-57-2
Molecular weight
234.38 g/mol
Appearance
Colourless to pale yellow liquid
Solubility
soluble in ethanol; insoluble in water
Flash point
111 °C
Also known asOTNEIso E SuperAmbergris Ketone
Performance
Note positionBase
Odour strengthMedium
Tenacity on strip~172 h
Fleeting2 weeks+
Odour profile
Woody · Amber
Velvety cedarwoodsoft amberdryslightly vetiver-like
Regulatory
IFRA restricted
20% Max. in fine fragrance
(IFRA Category 4)

EU: Added to the EU's expanded fragrance-allergen list (Regulation 2023/1545): declare on EU cosmetic labels above 0.001% (leave-on) or 0.01% (rinse-off).

Limits for other product types differ. Always check the current IFRA Standards and your local cosmetic regulations before finalising a formula.

Same molecule

Also available as

Formulating with this material?

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